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KMID : 0387720150260030291
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Korean Journal of Blood Transfusion
2015 Volume.26 No. 3 p.291 ~ p.299
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Korean Red Cross HLA-Matched Platelet Donor Registry
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권소영:Kwon So-Young
이선아:Lee Sun-Ah/임아현:Lim A-Hyun/조남선:Cho Nam-Sun/정철호:Jung Cheol-Ho/양진혁:Yang Jin-hyuk/박경운:Park Kyoung-Un
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Abstract
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Background: Transfusion of HLA-matched platelets is required when development of platelet refractoriness occurs after repeated platelet transfusion. This study was conducted to establish a HLA-matched platelet donor registry to supply matched platelets to patients who develop platelet refractoriness.
Methods: HLA-matched platelet donors were recruited among plateletpheresis donors. HLA-A and HLA-B antigen types of recruited donors were tested using a polymerase chain reaction-sequence specific oligonucleotide probe method.
Results: A total of 1,029 plateletpheresis donors were recruited. HLA-A and HLA-B antigen frequencies of recruited donors were similar to those of previously reported HLA antigen frequencies of Koreans. During the study period, a patient with platelet refractoriness recovered after receiving six units of HLA-matched platelets.
Conclusion: During this study 1,029 donors were registered as HLA-matched platelet donors and a patient with platelet refractoriness received HLA-matched platelets using this registry. Supply of HLA-matched platelets will be facilitated by continuous expansion of the number of registered HLA-matched platelet donors, development of a program for management and searching for HLA-matched donors, and establishment of a request-supply system between hospitals and the Korean Red Cross through further studies.
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KEYWORD
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HLA-matched platelet, Donor registry, Platelet refractoriness
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